New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Rare cases of liver disease. There were 88 in the control group and 81 in the Pycnogenol group. Commonly called arthritis, osteoarthritis is caused when the cartilage on your joints begins to wear down. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. 1. Another 2006 study examined the effects of the antioxidant activity of pine bark extract on oxidative stress, which is thought to be one of the nongenetic factors contributing to ADHD. The first studied group included 66 healthy subjects in whom the number of muscle cramps was recorded two weeks before entering the study and during the fourth and fifth week. This makes it very hard to set a standard dose. But a month after pycnogenol was stopped, the symptoms came back, suggesting that it may need to be used regularly to achieve the benefits [41]. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. WebMD does not provide medical advice, diagnosis or treatment. Lowers Blood Pressure. Start with a low dose so you can be sure it doesnt cause any side effects. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Furthermore, when CHS was suppressed by 71% with exogenous treatment with cis-urocanic acid, the putative epidermal mediator of photoimmunosuppression, 0.2% Pycnogenol lotion reduced the immunosuppression to 18%. Clearer skin, healthier hair there are a lot of claims about the health benefits of biotin. They also had normalized fasting glucose levels and blood pressure, which can also reduce a persons risk of heart problems. High-dose Pycnogenol (360 mg/day) for 4 weeks had the same LDL-lowering benefits in another study of 40 people [32, 56]. Top 9 Natural Allergy Relief Home Remedies - Dr. Axe 1 week ago from draxe.com Eat an Anti-Inflammatory, Alkaline Diet. The studies revealed that the sperm concentration greatly increased after about eight to 16 weeks of treatment, to include improved orgasmic function. A 2015 review indicates that pine bark extract can be used to treat metabolic syndrome and related disorders such as obesity, diabetes, and high blood pressure. Beta 1-3D Glucan is recognized by cells in the immune system, and can modify your immune system responses. In the study, the placebo group had higher IgE antibodies to the birch allergen than those who took Pycnogenol during the allergy season [17]. 5) Vein Diseases and Swelling. 5. Chewing gum with Pycnogenol (2.5 mg/piece) for 4 weeks reduced bad breath and mouth bacteria in a trial of 22 people [57]. It also slightly decreased blood pressure and increased testosterone [67]. In mice, luteolin prevented inflammation and allergic response in the lungs and nose by inhibiting inflammatory cytokines: IL-4, IL-5, and IL-1 3 []. Various brands of pycnogenol are available. The positive improvements in symptoms were greater among those taking Pycnogenol. The usual recommended duration of treatment for topical application is 7 days for Pycnogenol cream and 6 weeks for Pycnogenol powder. The top benefits of nattokinase include the following: Regulate blood pressure. Study participants took pine bark extract as a supplement, and it was found to be most effective in women who started out with dry skin. (8). Memorial Sloan-Kettering Cancer Center web site: "About Herbs: Pine Bark Extract. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. Pycnogenol (up to 200 mg/day) may improve asthma and reduce inflammatory asthma markers in the blood, leukotrienes, after 4 weeks, according to a randomized placebo-controlled trial of 26 asthma patients [14]. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. DOI: Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, 50 to 450 milligrams of pine bark extract daily, Supplements During Pregnancy: Whats Safe and Whats Not, The ADHD Diet: What Works and What Does Not, Berberine A Powerful Supplement With Many Benefits, The Top Health Benefits of Prunes and Prune Juice, What to Know About Andrographis Supplements: Potential Benefits and Uses, Kerry Boyle D.Ac., M.S., L.Ac., Dipl. (4). Researchers suggest that Pycnogenol may reduce cough, night-awakenings, improve airway flow, and the need for additional asthma medication [16]. You can refer to the National Institutes of Healths dosage guidelines for specific conditions. Both supplements are antioxidants, which have been shown to help with blood flow and erectile function. All rights reserved. If you take any medications regularly, talk to your doctor before you start using pycnogenol supplements. Can Pycnogenol help? 7. Disclaimer: Results are not guaranteed*** and may vary from person to person***. Pycnogenol seems well-tolerated for use in adults for up to 6 months. Enzogenol, a slightly different pine bark extract, may help improve brain function after mild concussions. Eighty-six patients were treated either with Pycnogenol at 150 mg or 300 mg daily or the drugs diosmin and hesperidin (Daflon)at 1,000 mg daily for two months. Blood clots form as a result of platelet aggregation, which is the platelets in the blood clumping together. This article explains which supplements are believed to be safe during pregnancy and which ones you should avoid. Inhibits platelet aggregation like low-dose aspirin. In one study, 10 patients were treated with placebo and 30 patients were treated with Pycnogenol (100 mg twice or three times daily for two months). But what makes this miracle ingredient so amazing? View as: Grid List. It may cause side effects such as: Risks. We all know the power of antioxidants to improve health and thehigh-antioxidant foodswe should eat regularly. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. - Apply a hot compress to the anus or soaking it in a shallow tub of hot water several times a day. In a smaller study of 58 people, pycnogenol reduced the inflammatory marker CRP [49, 50]. We don't yet know what the best dose to use is, but studies have used two 50 mg Pycnogenol capsules per day. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. The goal of this study was to evaluate if Pycnogenol could prevent deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) in eight-hour flights in 196 subjects at risk of these conditions. But the actual bioavailability of this complex mixture is still unknown. There is insufficient evidence to support the use of Pycnogenol for any of the uses listed below. Optimal doses of pycnogenol have not been set for any condition. However, with the addition of twice-daily Pycnogenol, normal erection increased to 80%, which further increased to 92.5% during the third month on thrice-daily Pycnogenol. Studies were conducted in Turkey on subjects who underwent abdominal surgery to determine if the pine bark extract could help reduce the inflammation. Pycnogenol: A miracle component in reducing ageing and skin disorders. This article reviews tongkat ali, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Chemistry. Pine bark extract is composed of 80% to 85% proanthocyanidins, the monomers catechin and taxifolin (5%), and phenolic acids, including derivatives of benzoic and cinnamic acids (2% to 4%). However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. Although these may still be high quality, the active compounds are more likely to vary. In a study of 20 postmenopausal women, 12 weeks of pycnogenol supplementation improved hydration and elasticity of the skin. Some risks associated with Pycnogenol include:, Pycnogenol and other maritime tree barks have not been studied as extensively as traditional medicine. The treatment was four 50 mg capsules of Pycnogenol. Studies on human subjects have reported few side effects - even . DOI: Scheff SW, et al. He learned about the seemingly omnipotent antioxidant within it and how those antioxidants increase the absorption of vitamin C. Continued research showed that the pine bark contained flavonols and bioflavonoids, which hold tissue-repairing properties. The study participants symptoms started to return a month after they stopped taking pine bark extract. These benefits appeared to persist for some time even after stopping supplementation [72]. Instead, use plain water to wipe yourself and then dry your bottom afterward. ( 4) Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Boost gastrointestinal health. People who use the supplement along with their traditional medication usually take smaller doses than those who only take the supplement. Its been noted that taking OPCs and vitamin C supplements at the same time could increase blood pressure if you have hypertension. Vertigo. Pine bark extract may be the perfect treatment since its an antioxidant dynamo. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. Align your health hacks with your genes for optimal health & cognitive function. Pycnogenol French maritime pine bark extract acts as a potent blend of antioxidants, it is a natural anti-inflammatory, stimulates generation of collagen and hyaluronic acid and help with natural dilation of blood vessels by supporting production of nitric oxide. That said, there are some instances where this extract may possibly be effective. Here are the many health benefits believed to be possible with Pycnogenol: Reduces "leaky" blood vessels by making the wall proteins (collagen, elastin) more resistant to damage. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for . Andrographis is a medicinal herb used to treat many health conditions, such as the common cold, osteoarthritis, and ulcerative colitis. Researchers suggest this effect may be due to reduced dopamine and adrenaline levels and increased glutathione levels. In another study, 61 children with ADHD were given one mg per kg/day of Pycnogenol or placebo over four weeks. 10 Day Erection Delay Sex Pills. High levels of both of these are considered risk factors for heart disease. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Pycnogenol (pic-noj-en-all) is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits. In combination with Mirtoselect, Pycnogenol may improve blood flow to the eye and reduce eye blood pressure as shown in a trial of 38 people [81]. Skin irritation. Another highlight of grapes nutrition is the presence of polyphenols, which have been shown to decrease chronic inflammation. If youre native to Oregon, you likely know all about marionberries. This plant extract also shows promise in such far-flung conditions as traumatic brain injury 40,41, skin problems 37, pain syndromes 38,39, and even tinnitus . Sign Up for the Latest Health News and Tips, Home Food and Nutrition Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies. Due to its anti-inflammatory properties, luteolin is being researched as a potential complementary treatment for multiple . Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. It also reduced the size of scars. Placebo capsules were given to control subjects at the same times. For allergies: 50 milligrams twice daily. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). Pycnogenol also treatment improved blood vessel function. Speak with your doctor before supplementing. Ana received her MS in Pharmacy from the University of Belgrade. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. You may want to start slow, taking smaller amounts, to ensure that your body works well with the OPCs found in pine bark extract. Pine bark extract comes from the inner bark of the Pinus pinaster tree, most commonly found in Europe. After taking a break for one to two weeks, they can start taking it again for several weeks. Here are some basic guidelines as reported by WebMD: While most studies do not indicate major side effects, pine bark extract may cause irritability and fatigue, and could interact with other drugs. She is a strong advocate of integrating scientific knowledge and holistic medicine. A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. Rakel, D. Integrative Medicine, 3rd edition, Saunders, 2012. Today, I want to share with you my secrets to reduce sugar Top 7 Benefits of Green Tea: The No. In oneparticular study published in Research in Pharmaceutical Sciences, researchers investigated the antibacterial activity of pine bark extract essential oil on staph infections, E. coli and pseudomonas infections. Its true. In some people lung inflammation is caused by leukotrienes chemicals that are released by the body after a person encounters allergens. Pycnogenol is a substance taken from the pine bark of trees found in the southwest region of France. According to researchers, it may help prevent the rise in free radicals typically seen after exercise, which could cause muscle fatigue and damage [9]. Pycnogenol is known under different names in some countries, such as Oligopin, and Flavangenol in Japan [4, 5]. DOI: Marini A, et al. This is thought to be due to pine bark extracts ability to reduce oxidative stress and inflammation. The goal of one study was to evaluate whether or not Pycnogenol could prevent edema (fluid build-up) during long-haul flights in healthy people. The women taking Pycnogenol also experienced improvement in fatigue, sleep, concentration, memory, dizziness, and mood, including less irritability. Score one for diabetes control and fewer risk factors for the heart. A trial of 86 people with eye damage from diabetes found that antioxidant therapy (including pycnogenol, vitamin E, and Coenzyme Q10) may improve eye health and reduce reactive oxygen species levels [35]. A total of 40 patients with retinopathy (damage to the retina part of the eye) from diabetes and other vascular causes were enrolled in one study. A 2004 animal study also found that applying a gel containing pine bark extract sped up the wound-healing process. DOI: Luzzi R, et al. A high number signals high blood pressure. Pycnogenol may reduce glucose levels, but it doesnt appear to increase insulin production or insulin sensitivity. In a good-quality study, 24 adults aged 24 to 53 years old with attention deficit hyperactivity disorder (ADHD) were given Pycnogenol, placebo, or the standard drug for three weeks. Pycnogenol also potentially improved cognitive function in 78 people with mild cognitive impairment. SelfDecode does not treat, diagnose or cure any conditions, Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. SelfDecode is a personalized health report service, (2006). Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Helps Treat Erectile Dysfunction. Normalization of cardiovascular risk factors in peri-menopausal women with Pycnogenol [Abstract]. A combination supplement (pycnogenol with collagen, coenzyme Q10, and other ingredients) reduced skin aging, elasticity, hydration, and tonicity in a study of 30 women [65]. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. If you are taking blood thinners, do not take pine bark extract or Pycnogenol unless approved by your doctor. Dr. Drew explains the benefits of probiotics for the gut microbiome and talks about the rise of leaky gut, and Dr. Steve shares how emotional stress can have real physical effects on the heart. Pycnogenol (100 mg/day) given to 44 older healthy people with high oxidative stress improved cognitive function, attention, mental performance, and reduced oxidative stress after 12 months [21]. However, healthy people are not immune and can also develop mild infections, in particular after being in improperly chlorinated hot tubs or swimming pools. Pain score in the Pycnogenol-treated group was reduced by 56%, as compared to 9.6% reduction in the placebo group. Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. She loves communicating science and empowering people to achieve their optimal health. All of our content is written by scientists and people with a strong science background. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. Disease of the retina in the eye. Some studies also suggest it can help guard against coronary artery disease and blood clots, per webmd.com. In the control group, there were five thrombotic events; whereas the Pycnogenol-treated subjects only experienced nonthrombotic, local flare-ups. While the aspirin reduced the risk for cardiovascular disease and colorectal cancer, among other cancers, the risk of gastrointestinal bleeding outweighed those benefits, creating more risks to the body. The most effective blood sugar-lowering dose was 200 mg/day higher doses had no further benefit [33]. Pycnogenol has been shown to help relieve the pain associated with osteoarthritis by keeping blood chemicals from attacking the cartilage. Quality and active ingredients in supplements may vary widely from maker to maker.
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